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Zhyrov e emulsyy parenteral POWER | SMOFlipid emulsion for infusion of 20% 500 ml bottles of 10 pieces

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Description

Release form

Infusion emulsion 20%

Packing

Bottle 500 ml.

Pharmacological action

CMOFlipid – supplementing the deficiency of essential fatty acids, compensating for the deficiency of energy substrates in the body.

Pharmacodynamics

CMOFlipid is identical in particle size and biological properties to endogenous chylomicrons. The components of the drug – soybean oil, medium chain triglycerides, olive oil and fish oil – in addition to differences in composition and energy value, have their own pharmacodynamic properties.

Soybean oil contains a large amount of essential fatty acids. It is most rich in linoleic acid (approximately 55-60%), which is a -6-fatty acid. 8% of the composition of soybean oil is represented by -Linolenic acid, which is -3-fatty acid. This part of the drug provides the necessary amount of essential fatty acids.

Medium chain fatty acids provide the body with rapidly available energy due to their ability to oxidize rapidly.

Olive oil supplies energy in the form of monounsaturated fatty acids, which are much less susceptible to oxidation compared to the corresponding amount of PUFA.

Fish oil is high in eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. DHA is an important structural component of cell membranes, and EPA is a precursor to eicosanoids such as PG, thromboxanes and LT.

Vitamin E protects unsaturated fatty acids from peroxidation.

Pharmacokinetics

Different triglycerides in the composition of SMOFlipid have different clearance indicators, but SMOFlipid is eliminated on average (as a mixture) faster than long chain tryglycerides (LCT). The lowest clearance of all components is in olive oil (slightly lower than that of LCT), and the highest clearance is in medium chain triglycerides (MCT). Fish oil in an LCT mixture has the same clearance as pure LCT.

Indications

Complete or partial parenteral nutrition as a source of energy and essential fatty acids including U-3 fatty acids, when oral or enteral nutrition is impossible, insufficient or contraindicated prevention and treatment of insufficiency (deficiency) of essential fatty acids, including -3 fatty acids.

Contraindications

hypersensitivity to fish proteins, eggs, soybeans, peanuts or components of the drug

severe hyperlipidemia

severe hepatic insufficiency

severe coagulation disorders

severe renal failure severe disease decompensated diabetes mellitus, acute myocardial infarction, stroke, embolism, metabolic acidosis, severe sepsis, hypotonic dehydration).

pulmonary edema

hyperhydration

decompensated heart failure.

Precautions: impaired fat metabolism, which can be observed in patients with renal failure, diabetes mellitus, pancreatitis, impaired liver function, hypothyroidism and sepsis. Clinical experience with the use of SMOFlipid in patients with diabetes mellitus and renal failure is limited.

Composition

Active ingredients: soybean oil (refined) 60 g, triglycerides with an average long chain 60 g, olive oil (refined) 50 g, purified fish oil 30 g

Dosage and administration

For infusion into the central or peripheral vein. The dose and rate of infusion should be determined by the patient’s ability to eliminate intravenously administered lipids. The standard dose is 1-2 g of fat / kg body weight / day, which corresponds to 5-10 ml of the drug / kg / day.

Maximum daily dose: 2 g fat / kg / day, which corresponds to 10 ml of the drug / kg / day.

The recommended infusion rate is 0.125 g fat / kg body weight / h, which corresponds to 0.63 ml of CMOFlipid / kg body weight / h. The infusion rate should not exceed 0.15 g fat / kg body weight / h, which corresponds to 0.75 ml of SMOFlipid / kg body weight / h.

Side effects

From the respiratory system, chest and mediastinal organs: rarely – shortness of breath.

From the gastrointestinal tract: infrequently – loss of appetite, nausea, vomiting.

From the vessels: rarely – lowering blood pressure, increased blood pressure.

General disorders and disorders at the injection site: often – mild fever rarely – chills rarely – hypersensitivity reactions (anaphylactic and anaphylactoid reactions, skin rash, urticaria, hyperemia, headache), a feeling of warmth or cold, pallor, cyanosis, pain in the neck, chest and lower back.

From the genitals and mammary glands: very rarely – priapism.

Drug Interactions

Clinical use of heparin causes a transient increase in lipoprotein lipase secretion into the bloodstream. At first, this can lead to an increase in plasma lipolysis, and then to a temporary decrease in the clearance of triglycerides.

Soybean oil is a source of natural vitamin K1. However, the content of this vitamin in the SMOFlipid preparation does not have a significant effect on the blood coagulation process in patients treated with indirect anticoagulants – coumarin derivatives.

Adding other medications or drugs to the SMOFlipid emulsion is usually not recommended, unless proven to be compatible.

SMOFlipid can be mixed with fat-soluble (Vitalipid) and water-soluble (Soluvit) vitamins.

SMOFlipid under aseptic conditions can be mixed with solutions of amino acids, glucose and electrolytes to obtain a solution for parenteral nutrition “all in one”.

When prescribing SMOFlipid with other infusion media (for example, solutions of amino acids, glucose) through the usual system for intravenous infusion, the compatibility of the solutions and emulsions must be guaranteed.

Overdose

Reduced ability to eliminate triglycerides can lead to the development of fat overload syndrome, which can be caused by an overdose of any fat emulsions. It is necessary to pay attention to possible signs of metabolic overload. The causes of impaired lipid metabolism can be genetic (an individual difference in metabolism), in addition, present or previous diseases can affect fat metabolism. This syndrome can also develop during severe hypertriglyceridemia, even at the recommended infusion rate, and be accompanied by a sudden change in the clinical condition of the patient, for example, the occurrence of renal failure or infection. Fat overload syndrome is characterized by hyperlipemia, fever, fatty infiltration, hepatomegaly with or without jaundice, splenomegaly, leukopenia, thrombocytopenia, blood clotting disorders, hemolysis, reticulocytosis, pathological results of functional liver tests and the development of coma. Stopping the infusion of the fat emulsion leads to the disappearance of all symptoms.

Storage Conditions

In a dry, dark place, at a temperature not exceeding 20 ° C.

Expiration

2 years.

Active ingredient

Fat emulsions for parenteral nutrition

Terms leave through pharmacies

In retseptu

lekarstvennaja form

эmulsyya for infusions

Fresenius Kabi, Germany

Additional information

Brand

3 reviews for Zhyrov e emulsyy parenteral POWER | SMOFlipid emulsion for infusion of 20% 500 ml bottles of 10 pieces

  1. Jennifer

    Items came in a timely manner. Great to work with. Thanks….

  2. James

    great service

  3. Megan

    received quickly, as described

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