Infusion solution 0.9% transparent, colorless.
It has a detoxifying and rehydrating effect. Replenishes sodium deficiency in various pathological conditions of the body and temporarily increases the volume of fluid circulating in the vessels.
The pharmacodynamic properties of the solution are due to the presence of sodium ions and chloride ions. A number of ions, including sodium ions, penetrate the cell membrane using various transport mechanisms, among which the sodium-potassium pump (Na-K-ATPase) is of great importance.
Sodium plays an important role in signaling in neurons, electrophysiological processes of the heart, as well as in metabolic processes in the kidneys.
Sodium is excreted mainly by the kidneys, however, while a large amount of sodium undergoes reabsorption (renal reabsorption). A small amount of sodium is excreted in feces and during perspiration.
– isotonic extracellular dehydration
– dilution and dissolution of parenteral drugs (as a base solution).
– hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration
– circulatory disorders that threaten brain and pulmonary edema
– cerebral edema, pulmonary edema, acute left ventricular failure, concomitant administration of corticosteroids in large doses.
When adding other drugs to the solution, contraindications to these drugs should be considered.
Precautions: decompensated chronic heart failure, arterial hypertension, peripheral edema, preeclampsia, chronic renal failure (oligo-, anuria), aldosteronism and other conditions associated with sodium retention in the body.
Use during pregnancy and lactation
Data on the use of the drug during pregnancy and during breastfeeding are insufficient.
It is possible to use during pregnancy and during breastfeeding in cases where the expected benefit to the mother outweighs the possible risk of complications.
During any infusion, it is necessary to monitor the patient’s condition, the clinical biological indicators, it is especially important to evaluate blood plasma electrolytes.
In the body of children, because of the immaturity of renal function, sodium excretion may slow down. Therefore, in such patients, repeated infusions should be carried out only after determining the concentration of sodium in the blood plasma.
If hypersensitivity reactions or infusion reactions occur, the infusion should be stopped immediately and the necessary therapeutic measures indicated.
Depending on the volume and rate of infusion against the background of intravenous administration of the drug, there is a risk of developing hypervolemia and (or) overload with dissolved substances and disturbances in the balance of electrolytes.
In patients with renal failure, the drug should be used with extreme caution or not at all. The use of the drug in such patients can lead to sodium retention.
Use only a clear solution, with no visible inclusions and if the packaging is not damaged. Enter immediately after connecting to the infusion system. The solution should be administered using sterile equipment in compliance with aseptic and antiseptic rules. In order to avoid air entering the infusion system, it should be filled with a solution, releasing the residual air from the container completely.
As with all parenteral solutions, the compatibility of the added substances with the solution should be determined before dissolution. Drugs known as incompatible with it should not be used with 0.9% sodium chloride solution.
The doctor must determine the compatibility of the added drug with a 0.9% sodium chloride solution by checking for possible discoloration and / or the appearance of a precipitate, insoluble complexes or crystals. Before adding, it is necessary to determine whether the added substance is soluble and stable in water at a pH level, as in the sodium chloride solution of 0.9%. When adding the drug, it is necessary to determine the isotonicity of the resulting solution before administration.
Before adding drugs to the solution, they must be thoroughly mixed in compliance with aseptic rules. The prepared solution should be introduced immediately after preparation, do not store! Every unused dose should be disposed of.
Sodium chloride 9 g,
water for injection up to 1 l.
Dosage and Administration
Intravenously (usually drip). The required dose can be calculated in mEq or mmol of sodium, mass of sodium ions or mass of sodium chloride (1 g NaCl = 394 mg, 17.1 mEq or 17.1 mmol of Na and Cl).
The dose is determined depending on the condition of the patient, the loss of body fluid, Na + and Cl-, age, body weight of the patient. Serum concentrations of electrolytes in plasma and urine should be carefully monitored.
The dose of sodium chloride solution for adults is from 500 ml to 3 liters per day.
The dose of sodium chloride solution for children is from 20 ml to 100 ml per day per kg body weight (depending on age and total body weight). The rate of administration depends on the condition of the patient.
The recommended dose when used to dilute and dissolve parenteral-administered drugs (as a basic solvent solution) is in the range from 50 ml to 250 ml per dose of the drug administered.
In this case, the dose and rate of administration of the solution are determined by the recommendations for the use of the drug administered.
Acidosis, hyperhydration, hypokalemia.
When used correctly, undesirable effects are unlikely.
When using sodium chloride 0.9% solution as a base solution (solvent) for other drugs, the probability of side effects is determined by the properties of these drugs.
In this case, if adverse reactions occur, you should suspend the administration of the solution, evaluate the patient’s condition, take adequate measures and save the remaining solution for analysis, if necessary.
If any of the side effects listed in the instructions get worse, or you notice any other side effects, not specified in the instructions, inform your doctor.
Compatible with colloidal hemodynamic blood substitutes (mutual enhancement of effect).
When mixed with other medicines, compatibility is visually monitored.
Symptoms: nausea, vomiting, diarrhea, spastic abdominal pain, thirst, decreased salivation and lacrimation, increased sweating, fever, tachycardia, increased blood pressure, renal failure, peripheral pulmonary edema, edema dizziness, anxiety, irritability, weakness, muscle cramps and stiffness, generalized convulsions, coma and death.
Excessive administration of 0.9% sodium chloride solution can cause hypernatremia.
Excessive intake of chloride in the body can lead to hyperchloremic acidosis.
If a 0.9% sodium chloride solution is used as a base solution for diluting and transporting other drugs, symptoms and complaints of excessive administration are most often associated with the properties of the drugs added to the solution.
In case of unintentional excessive administration of the solution, treatment should be discontinued and the patient’s condition evaluated.
Sodium chlo reed
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