Syrup for children.
Rimantadine – an antiviral agent, adamantane derivative is active against various strains of influenza A. Being a weak base, rimantadine acts by increasing the pH of endosomes that have a vacuole membrane that surrounds the viral particles after they enter the cell. The prevention of acidification in these vacuoles blocks the fusion of the viral membrane with the endosome membrane, thus preventing the transmission of viral genetic material into the cytoplasm of the cell. Rimantadine also inhibits the release of viral particles from the cell, i.e. interrupts the transcription of the viral genome.
Prevention and early treatment of influenza A in children older than 1 year.
Prophylaxis with rimantadine can be effective in contact with patients at home, with the spread of infection in closed groups, and at high risk of the disease during an influenza epidemic.
acute liver disease
acute and chronic kidney disease
pregnancy and lactation
children under 1 year
increased sensitivity to rimantadine and malignant glucose
Epilepsy (including history), severe chronic renal failure, liver failure, diabetes mellitus.
Due to the presence of sorbitol in the composition should be taken with caution in case of vomiting, pain and discomfort in the abdomen, diarrhea.
Use during pregnancy and lactation
Use of the drug is contraindicated in pregnancy. If necessary, use during lactation should stop breastfeeding.
The use of rimantadine within 2-3 days before and 6-7 hours after the onset of clinical manifestations of type A influenza reduces the severity of disease symptoms and the degree of serological reaction. Some therapeutic effect may also occur if rimantadine is prescribed within 18 hours after the onset of the first symptoms of influenza.
During use, exacerbation of chronic concomitant diseases is possible.
In patients with epilepsy with rimantadine, the risk of developing an epileptic seizure increases. 15 ml of syrup corresponds to 1 bread unit (XE), which should be considered when prescribing the drug to patients with diabetes.
Possible drug-resistant viruses.
Sorbitol can cause abdominal discomfort and a laxative effect. In the case of the development of such effects during treatment, the drug should be discontinued and consult a doctor.
Due to the increased risk of dyspeptic symptoms, it is not recommended to take it simultaneously with foods containing a significant amount of sorbitol (prunes, etc.).
Effect on the ability to drive vehicles and mechanisms
Given the likelihood of side effects from the central nervous system, caution should be exercised when driving vehicles and mechanisms.
Active ingredient: rimantadine hydrochloride – 2.0 mg
Excipients: sorbitol (liquid sorbitol) – 514.3 mg, maltitol (liquid maltitol) – 514.3 mg, sodium carmellose – 3.64 mg, methyl parahydroxyb 1.15 mg, strawberry flavor 0.63 mg, purified water up to 1 ml.
Dosage and administration of
Take orally (after eating) with water, according to the following scheme: for children from 1 year to 3 years old – 10 ml (2 teaspoons) of syrup (20 mg) on ??the first day 3 times a day (daily dose – 60 mg) 2 and 3 days – 10 ml 2 times a day (daily dose – 40 mg), 4 days – 5 day – 10 ml 1 time per day (daily dose – 20 mg )
For children from 3 to 7 years old – on the first day – 15 ml (3 teaspoons) of syrup (30 mg) j times a day (daily dose – 90 mg) 2 and 3 days – 3 teaspoons 2 times a day (daily dose – 60 mg), 4 days – 5 days – 3 teaspoons 1 time per day (daily dose – 30 mg).
For children from 7 to 10 years old, 25 ml (5 teaspoons) of syrup (50 mg) 2 times a day for 5 days (daily dose is 100 mg).
For children from 11 to 14 years old, 25 ml (5 teaspoons) of syrup (50 mg) 3 times a day for 5 days (daily dose is 150 mg).
For prophylaxis use:
for children from 1 year to 3 years old – 10 ml (2 teaspoons) of syrup (20 mg) once a day,
for children from 3 to 7 years old – 15 ml ( 3 teaspoons) syrup (30 mg) 1 time per day,
for children over 7 years old – 25 ml (5 teaspoons) of syrup (50 mg) 1 time per day for 10-15 days.
Attention! The daily dose of rimantadine should not exceed 5 mg per kg of body weight.
Side effects of
From the cardiovascular system: tachycardia, heart failure,
heart block, palpitations, arterial hypertension, impaired cerebral circulation, loss of consciousness.
From the side of the nervous system: insomnia, dizziness, headache, irritability, fatigue, impaired attention, movement disorders, drowsiness, depressed mood, euphoria, hyperkinesia, tremors, hallucinations, confusion, convulsions.
From the sensory organs: tinnitus, change or loss of smell.
From the respiratory system: shortness of breath, bronchospasm, cough.
From the gastrointestinal tract: nausea, vomiting, loss of appetite, dry oral mucosa, abdominal pain, diarrhea, dyspepsia.
From the rut and subcutaneous tissue: rash.
Pharmacodynamic: rimantadine reduces the effectiveness of antiepileptic drugs.
Pharmacokinetic: adsorbents, astringents and enveloping agents reduce the absorption of rimantadine.
Urine-acidifying agents (acetazolamide, sodium bicarbonate, etc.) increase the concentration of rimantadine.
Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%.
Cimetidine reduces rimantadine clearance by 18%.
The sorbitol contained in the preparation may affect the bioavailability of concurrently used drugs.
Due to the increased risk of dyspeptic symptoms, simultaneous administration with other medicines containing sorbitol is not recommended.
In some cases, if the recommended dose is exceeded, tearing of the eyes and pain in the eyes, frequent urination, fever, constipation, sweating, inflammation of the oral mucosa, dry skin are observed.
Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions. Rimantadine is partially excreted during hemodialysis.
Terms and conditions