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Propofol |

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$32.00 $23.00

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SKU: BID494977 Category: Tag:

Description

Release form

Emulsion for intravenous injection

Packing

5 ampoules of 20 ml.

Pharmacological action

Propofol is a fast-acting intravenous anesthetic for the introduction and maintenance of general anesthesia, as well as for sedation of patients during intensive care.

According to the general opinion, this anesthetic causes a non-specific effect at the level of lipid membranes. In most patients, general anesthesia occurs after 30-60 seconds.

The duration of anesthesia, depending on the dose and related drugs, is from 10 minutes to 1 hour. From anesthesia, the patient wakes up quickly and with a clear consciousness. The opportunity to open your eyes appears after 10 minutes. No specific adsorption sites have been established.

When using Propofol for induction of anesthesia and for maintaining it, a decrease in average blood pressure and small changes in heart rate are observed. However, hemodynamic parameters usually remain relatively stable while maintaining general anesthesia and the frequency of adverse hemodynamic changes is low.

Although respiratory depression may occur after administration of Propofol, any effects are qualitatively similar to those that arise when using other intravenous drugs for anesthesia, and are easily controlled in a clinical setting.

Propofol reduces cerebral blood flow, intracranial pressure and reduces cerebral metabolism. A decrease in intracranial pressure was significant in patients with an increased baseline value of intracranial pressure.

Indications

Propofol is used: in adults and children older than 1 month for general intravenous anesthesia with a short-term effect of

in adults and children older than 1 month for induction anesthesia and for maintaining

in adults and children over 16 years of age to provide a sedative effect, receiving intensive care and being on mechanical ventilation

in adult conscious, in order to ensure a sedative effect during surgical and diagnostic procedures.

Contraindications

Hypersensitivity to one of the components of the drug, children up to 1 month.

Propofol is contraindicated for sedation in patients under 16 years of age during intensive care.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

Special instructions

In cases where there is a likelihood of side effects associated with activation of the vagus nerve, it is advisable to administer an cholinolytic before anesthesia. Should not be used in obstetric practice.

The risk of pain along the vein can be significantly reduced by infusion through large veins or with the administration of a lidocaine solution.

Injection can only be done by specially trained personnel with the possibility of immediate use of mechanical ventilation, oxygen therapy, resuscitation in full.

Composition

1 ml emulsion contains: propofol 10 mg

excipients: soybean oil, egg lecithin, glycerin, oleic acid, sodium hydroxide, water for injection

Dosage and administration of

IV, the dose is set individually.

General anesthesia for adults.

Introductory anesthesia: adults – 20–40 mg every 10 s until signs of anesthesia appear. Patients under 55 years of age usually require from 1.5 to 2.5 mg / kg, older than 55 years and patients of ASA classes III and IV, especially with heart failure – the dose should be reduced to 1 mg / kg and the rate of administration ( 20 mg every 10 s). Children over 3 years old – slowly until clinical signs of anesthesia appear. The dose is adjusted in accordance with the age and (or) body weight of the child. For children over 8 years old, the likely dose is 2.5 mg / kg. Younger children may require a higher dose. Children of classes III and IV by ASA are recommended a lower dose. Not recommended for use in children under 3 years of age.

Maintenance of anesthesia: for adults – in the form of a continuous infusion or repeated bolus injection. With prolonged infusion, the dose is usually in the range of 6-12 mg / kg.

In elderly patients, patients with severe general condition, patients with ASA classes III and IV, and patients with hypovolemia, the dose is reduced to a minimum of 4 mg / kg / h. Bolus injected from 25 to 50 mg of the drug.

For children older than 3 years – in the form of a continuous infusion or bolus injection, usually satisfactory anesthesia is provided at a rate of administration of 9-15 mg / kg / h.

Achieving a sedative effect: during intensive care, patients undergoing mechanical ventilation are advised to continue infusion at a rate of 0.3–0.4 mg / kg / h for diagnostic and surgical procedures, depending on the clinical picture, usually 0.5 –1 mg for 1–5 min to achieve the effect and 1.5–4.5 mg / kg / h for maintenance. To quickly achieve a deep sedative effect – 10–20 mg bolus.

Do not use in children under 16 years of age with surgical and diagnostic procedures to achieve a sedative effect.

The drug should not be used during pregnancy and during lactation, as well as as an anesthetic in obstetrics.

Do not mix with other injectable solutions except 5% glucose solution, lidocaine solution for injection, fentanyl solution for injection.

Side effects

decreased blood pressure,

bradycardia (sometimes severe),

short-term respiratory failure,

shortness of breath.

Rarely: convulsions,

opisthotonus,

pulmonary edema.

Drug Interactions

Compatible with medications for spinal and epidural anesthesia, with medicines used in premedication, muscle relaxants and analgesics.

Storage conditions

Do not store above 25 ° C.

Do not freeze.

The Expiration of

is 3 years.

active substance

Propofol

Terms leave through pharmacies

In retseptu

Dosage form

emulsion for infusions

Fresenius Kabi, Germany

Additional information

Brand

4 reviews for Propofol |

  1. Elizabeth

    Great as usual.

  2. Jing

    great product thx

  3. Matthew

    as described

  4. Mary

    Thank you. Great buy!

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