oxymetazoline |

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Pharmacological action of

Noxspray – -adrenomimetic, an imidazoline derivative, is a vasoconstrictor for topical use.

When it enters the nasal cavity, the drug narrows the arterioles of the mucous membrane of the nasal cavity, as a result of which edema, hyperemia, exudation are reduced, nasal breathing is restored, and nasal discharge is reduced.

Knoxspray also reduces the swelling of the mucous membrane around the opening of the Eustachian tube, improving drainage with Eustachitis and otitis media.

essential oils, which are part of the drug, help eliminate irritation of the nasal mucosa, protect it from excessive drying.


Local narrowing of the vessels of the nasal mucosa and sinuses occurs 5-10 minutes after injection of Noxspray into the nasal cavity and lasts up to 10-12 hours.


acute rhinitis of allergic or infectious and inflammatory etiology


nasal congestion and shortness of breath in colds

eustachitis, otitis media

to facilitate rhinoscopy and other manipulations.


hypersensitivity to the components of the drug

atrophic rhinitis

children under 6 years of age



The drug is used with caution in case of chronic heart failure, arrhythmia, severe atherosclerosis, arterial hypertension, thyrotoxicosis, diabetes mellitus, chronic renal failure, angle-closure glaucoma, prostatic hyperplasia with clinical symptoms while taking MAO inhibitors, tricyclic antidepressants.

To prevent the spread of infection, do not use one vial for several people. Avoid prolonged use and overdose of the drug. Long-term use of decongestants may lead to a decrease in their effectiveness. The abuse of these drugs can cause atrophy of the mucous membrane of the nasal cavity and reactive hyperemia with drug rhinitis.

Use during pregnancy and lactation

During pregnancy and breastfeeding, the drug is used when absolutely necessary, when the expected benefit to the mother outweighs the potential risk to the fetus or baby.

Special instructions

Use in pediatrics

Knoxspray is used in children from 6 years.

Effect on the ability to drive vehicles and control mechanisms

In recommended doses, the drug does not affect the rate of psychomotor reactions.

Sodium hydroxymethol Trilon B) benzalkonium chloride propylene glycol purified water oxymethazoline hydrochloride 500 mcg.

Dosage and administration

The tip of the nozzle of the bottle is introduced into each nasal passage and sharply pressed once on the bottle. During injection, air is drawn in by the nose. Do not bend your head back and turn the bottle over when injecting Knoxpray.

Children from 6 to 12 years of age are given 1 injection in each nasal passage 2 times a day, for children over 12 years of age and adults – 1-2 injections in each nasal passage 2 times a day.

Duration of use should not exceed 7 days.

Side effects

Sometimes: burning sensation or dryness of the nasal membranes, sneezing.

In rare cases: reactive hyperemia.

Repeated overdose with topical nasal administration leads to systemic sympathomimetic effects such as tachycardia, insomnia, anxiety, increased blood pressure, headache, and nausea.

Very rarely, with the use of Knoxpray, the development of severe hypersensitivity reactions (including Quincke’s edema) is possible.

In case of side effects, the drug should be discontinued and consult a doctor.

Drug Interactions

Noxspray should not be used simultaneously with other local vasoconstrictors and intranasal agents, as well as with tricyclic antidepressants and MAO inhibitors.

Overdose of

In case of a significant overdose or if used orally, the following symptoms may occur: myosis, nausea, vomiting, cyanosis, hyperthermia, tachycardia, arrhythmia, vascular insufficiency, arterial hypertension, respiratory distress, pulmonary edema, cardiac arrest, mental illness. Very rarely – inhibition of the central nervous system with the possible development of coma.

Treatment: in case of an overdose of the drug, the stomach is washed and symptomatic therapy is carried out.

Storage Conditions

The product should be stored out of the reach of children at a temperature not exceeding 25 ° C.

Term hodnosty

3 years

Terms leave through pharmacies

without prescription

Sperco, Ukraine

Additional information


4 reviews for oxymetazoline |

  1. Dustin

    foot powder arrived fast and as advertized, thanks

  2. Fahmi

    A+ Transaction

  3. Julian

    Thanks!!!! Arrived just as described 👍🏻

  4. Mike


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