Pharmaceutical action: Mupirocin is a broad-spectrum bacteriostatic antibiotic for topical application. It inhibits the synthesis of bacterial proteins by reversible and specific binding to isoleucyl-transport RNA synthetase.
Affects skin infections: Staphylococcus aureus (including methicillin-resistant strains), Staphylococcus epidermidis, Staphylococcus saprophyticus and Streptococcus pyogenes (including coagulase-negative strains).
Not cross-resistant with chloramphenicol, erythromycin, fusidic acid, gentamicin, lincomycin, methicillin, neomycin, streptomycin, tetracycline.
Pharmacokinetics: Mupirocin practically does not penetrate intact skin. In the case of absorption through damaged skin, it is metabolized to a microbiologically inactive metabolite – monic acid – and is rapidly excreted from the body by the kidneys.
Primary and secondary infectious skin lesions caused by microorganisms sensitive to mupirocin, including: – primary skin infections – pyoderma (streptoderma, staphyloderma): impetigo, sycosis, folliculitis, furunculosis (including ear lobe) shells),
ecthymes – secondary infections – infected eczema, infected atopic, contact and allergic dermatitis, infected injuries (abrasions, cuts, scratches, insect bites), trophic ulcers, minor (not requiring hospitalization) wounds and burns
– prevention of bacterial lesions and their complications arising from small wounds, cuts, pressure sores.
– hypersensitivity to any component of the drug Bonderm
– children under 3 years of age.
Precautions: renal failure (see “Special instructions”).
Pregnancy and lactation
There is currently insufficient data on the use of mupirocin in pregnancy, therefore, the use of the drug is possible if the expected benefit exceeds the possible risk of complications.
Excretion of the drug in breast milk is unlikely, however, the use of the drug in nursing mothers is possible if the expected benefit outweighs the risk of complications.
Macrogol, which is part of Bonderm ointment for external use, is absorbed from open wounds and damaged skin and excreted by the kidneys, so patients with severe chronic renal failure should be used with caution in large areas of the skin.
Avoid contact with eyes and mucous membranes. If the ointment enters the eyes and mucous membranes, it is recommended to thoroughly rinse them with water until the ointment remains completely removed.
In rare cases of allergic reactions or significant irritation of the skin when applying Bonderm ointment, treatment should be discontinued, rinse the affected area with water to remove ointment residues and prescribe alternative antibacterial therapy.
Influence on the ability to drive a car or perform work that requires an increased speed of physical and mental reactions. Adverse effects on the ability to drive vehicles and mechanisms were not observed.
1 g: – mupirocin 20 mg
macrogol 400 – 587 mg
macrogol 3350 – 393 mg
Dosage and Administration
A small amount of BondermÐÂ® ointment is applied to the affected skin surface 2-3 times a day. The course of treatment is up to 10 days, depending on the severity of the lesion. In the absence of a clinical effect after 5 days of treatment, it is recommended to review the diagnosis and further treatment tactics taking into account the dynamics of clinical indicators.
BondermÐÂ® Ointment can be applied using an aseptic dressing or applied under an occlusive dressing.
Children and elderly patients. No restrictions are required.
Impaired liver function. No correction required.
Impaired renal function. See “With caution.”
Bonderm® ointment is well tolerated.
Very rarely, burning, itching and dryness are observed at the site of application of the drug. Skin allergic reactions (edema at the site of application, rash) to mupirocin or ointment base were rarely observed.
When using the ointment in isolated cases, generalized allergic reactions have been reported.
Avoid concurrent use with other drugs for external use, as this may reduce the antibacterial activity or stability of mupirocin in the ointment.
No overdose has been reported to date.
Active E substance
Kormyashtim mamam in naznacheniyu Vrach Dlya vzrosl h in naznacheniyu Vrach Pregnant doctor by appointment
infection kozhy, Furunkul