Description
Release form
Yellow injection, clear.
Packaging
1 ml – glass syringes (1) complete with a needle for SC administration – contour cell packaging (1) – packs of cardboard.
Pharmacological action
Antitumor drug.
Indications
Acute lymphocytic leukemia, trophoblastic disease, skin cancer, cervical and vulvar cancer, esophageal cancer, squamous cell carcinoma of the head and neck, cancer of the renal pelvis and ureter, osteogenic and soft-cell sarcoma, Ewing’s sarcoma, lung cancer, breast cancer, germ cell tumors of the testis and ovaries, liver cancer, kidney cancer, retinoblastoma, medulloblastoma, penile cancer, lymphogranulomatosis.
Severe forms of psoriasis (in case of failure of standard therapy).
Severe form of rheumatoid arthritis (in case of failure of standard therapy).
Contraindications
Severe impairment of liver and / or kidney function, leukopenia, thrombocytopenia, pregnancy. Methotrexate should not be used in immunodeficiency conditions.
Use in pregnancy and lactation
Methotrexate is contraindicated in pregnancy. If necessary, use during lactation should stop breastfeeding.
Women of childbearing age should use reliable methods of contraception while using methotrexate.
In experimental studies, the embryotoxic and teratogenic effects of methotrexate have been established.
Composition
1 ml
methotrexate disodium 10.97 mg,
corresponding to the content of methotrexate 10 mg
Excipients: sodium chloride – 7 mg, sodium hydroxide solution 2M – 1.76 mg (22 μl), sodium benZoat solution 1M – up to pH 8.5 ± 0.1, water d / i – up to 1 ml.
Dosage and administration
Take orally, injected in / in, / m, intralumbal. Set individually, depending on the indications and stage of the disease, the state of the hematopoietic system, anti-tumor therapy regimen.
Side effects of the
Digestive system: possible ulcerative stomatitis, anorexia, gingivitis, pharyngitis, nausea rarely – diarrhea, melena, enteritis, pancreatitis in some cases (with prolonged daily use) – liver necrosis, cirrhosis, fatty atrophy, periportal liver fibrosis.
From the hemopoietic system: leukopenia, anemia, thrombocytopenia.
From the side of the central nervous system: feeling tired, dizziness rarely – headache, aphasia, drowsiness, cramps.
From the reproductive system: disorders of oogenesis and spermatogenesis, oligospermia, menstrual irregularities, decreased libido, impotence.
From the urinary system: hematuria, cystitis, severe renal impairment.
Allergic reactions: chills, decreased resistance to infection rarely – urticaria, toxic epidermal necrolysis, Stevens-Johnson syndrome.
Dermatological reactions: skin rash, photosensitivity, pigmentation disorders, telangiectasia, acne, furunculosis.
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