Pharmacological action of
Meloxidil refers to non-steroidal anti-inflammatory drugs (NSAIDs).
Meloxicam, which is part of Meloxidil, belongs to the NSAIDs of the oxycam group and has an anti-inflammatory, analgesic and antipyretic effect.
The mechanism of action of meloxicam is to suppress the production of cyclooxygenase (COX) in the arachidonic acid cycle, in this case, the production of COX-II is mainly suppressed, under the influence of which the synthesis of inflammatory prostaglandins (PGE1 and PGE2) occurs, causing inflammation, edema and pain.
After oral administration, meloxicam is well absorbed from the intestines of dogs and reaches a maximum plasma concentration within 7.5 hours the elimination half-life is 24 hours. Meloxicam is metabolized in the liver and excreted in the bile (75%) as a metabolite of glucururonic acid.
By the degree of exposure to the body, Meloxidil is a low-hazard substance (hazard class 4 according to GOST 12.1.007-76).
Meloxidil is used in dogs for the treatment of inflammation in acute and chronic diseases of the musculoskeletal system (arthritis, arthrosis, dislocation, edema, synovitis, tenosynovitis).
Individual hypersensitivity to meloxicam, gastric and duodenal ulcer, hemorrhagic syndrome, severe heart, liver and kidney failure, pregnancy and lactation, age up to 6 weeks.
Dosage and administration
Meloxidil is administered orally with food once a day at a dose of 0.2 mg / kg meloxicam on the first day of treatment, further in a maintenance dose of 0.1 mg / kg meloxicam for 10 days.
Before use, shake the contents of the vial until a homogeneous suspension is formed.
Each pack is equipped with two measuring syringes, which allows the most accurate dosage of the drug to small and large dog breeds. One division of a small syringe is designed for 0.5 kg of animal weight, a large syringe for 2.5 kg of animal weight, which corresponds to a daily maintenance dose of 0.1 mg / kg meloxicam.
The clinical effect occurs 3-4 days after the start of the drug. The duration of the course of treatment is determined by the veterinarian depending on the indications.
After a 10-day course of treatment, the animal must be examined by a veterinarian and, if there is no improvement in the clinical condition, the drug is discontinued.
In case of overdose of the drug, symptomatic treatment is recommended.
The use of the drug in animals in a state of dehydration, hypovolemia and hypotension is potentially dangerous, due to the possible toxic effect of meloxicam on the kidneys.
In case of emergency, when administering Meloxidil to such animals, the daily dose should be halved and careful monitoring of the clinical condition should be carried out.
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