Lactulose | Normase syrup 667 mg /ml 200 ml vials

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Transparent, colorless or light yellow with a brownish tint syrupy liquid.

Latin name


Release form



Bottle 200 ml.


Constipation: regulation of the physiological rhythm of colon emptying.

Stool softening for medical purposes (hemorrhoids, conditions after surgery on the colon and in the anus).

Hepatic encephalopathy: treatment and prevention of hepatic coma or precoma.


Lactose intolerance


intestinal obstruction

hypersensitivity to any component of the drug.

Patients with rare congenital disorders, such as galactose intolerance, lactase deficiency, or glucose-galactose malabsorption, should not use this medication.

Precautions: patients with hepatic (pre) coma, diabetes mellitus

rectal bleeding, undiagnosed

colostomy, ileostomy.

Use during pregnancy and lactation

If necessary, Normase® can be used during pregnancy and during breastfeeding.

Special instructions

In the absence of a therapeutic effect, consult a doctor within a few days.

Lactulose should be used with caution in patients with lactose intolerance.

Please note that Normase® may contain minor amounts of bound sugars (e.g. lactose, galactose, epilactose and fructose).

The dosage commonly used to treat constipation does not require correction for patients with diabetes mellitus. In the treatment of hepatic (pre) coma, higher doses of the drug are usually prescribed, which should be considered for patients with diabetes mellitus. Patients with rare congenital disorders such as galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption should not use this medication. When treating children, laxatives should be used in exceptional cases and under the supervision of a doctor. It must be borne in mind that during treatment, disorders of the emptying reflex may occur.

The use of Normase® does not affect or has a slight effect on the ability to drive a car and machinery.

Composition of

100 ml of the preparation contains:

active substance: lactulose solution (in terms of lactulose) – 66.7 g


citric acid -0.05 g,

cream flavor (No. 7 bis) -0.06 g,

purified water – up to 100 ml.

Flavor composition: propylene glycol,



Dosage and administration

The drug is intended for oral administration.

Lactulose solution can be taken both diluted and undiluted. It is necessary to immediately swallow the taken single dose without holding it in the mouth. All dosages must be selected individually.

In the case of a single daily dose, it must be taken at the same time, for example, during breakfast.

During laxative therapy, it is recommended that you take a sufficient amount of liquid (1.5-2 liters, which equals 6-8 glasses) per day.

Dosage for the treatment of constipation or for softening the stool for medical purposes:

The daily dose of lactulose can be taken once, or divided into two, using a measuring cup.

The initial dose may be adjusted to a maintenance dose depending on the reaction to taking the drug. The therapeutic effect may occur 2-3 days after the start of the drug.

For constipation: adults – in the first 3 days, 15–40 ml per day, then 10–25 ml. Children over 6 years old – in the first 3 days, 15 ml per day, then – 10 ml for 1-6 years – 5-10 ml per day, up to 1 year – 5 ml per day. The duration of treatment is from 4 weeks to 3-4 months.

With hepatic coma, precom, encephalopathy and hyperammonemia: the initial dose is 30-60 ml 3 times a day. Then the dose is selected so that the soft stool is 2-3 times a day. Treatment can last up to 3 months or more.

In case of dysbiosis and salmonellosis: adults – 15-30 ml 3-5 times a day, children over 8 years old – 45 ml per day, from 5 to 8 years old – 25 ml per day, from 1 to 5 years old – 15 ml in day, up to 1 year 5-15 ml per day. The duration of treatment is 10-12 days, repeated courses 3 times with weekly intervals.

In the postoperative period: adults – 10-30 ml 3 times a day, children older than 1 year 5-10 ml 2-3 times a day, up to 1 year – 5 ml 2 times a day. The drug is prescribed 18-24 hours after surgery for 3-5 days.

Side effects

Flatulence may occur in the first days of receiving lactulose. As a rule, it disappears in a few days. In the case of using high doses for a long time in the treatment of hepatic encephalopathy, the patient may develop electrolyte balance disorders due to diarrhea.

Gastrointestinal disorders: Flatulence, abdominal pain, nausea, vomiting. When high doses are used, diarrhea may occur.

Other disorders: Disorders of water-electrolyte balance due to diarrhea.

Drug Interactions

When used with antibiotics and antacids, lactulose is reduced.

Lactulose alters the pH-dependent release of intestinal drugs.

It is not recommended to take lactulose for 2 hours after taking other medicines.

Storage conditions

Store at a temperature of 15 to 25 ° C. Do not freeze.

Keep out of the reach of children.

Shelf suitability

3 Year

Molteni and Fratelli, Italy

Additional information


4 reviews for Lactulose | Normase syrup 667 mg /ml 200 ml vials

  1. James

    Fast shipping! Perfect item! Thanks

  2. Jack

    Excellent. Thanks

  3. Billy


  4. Ankur

    excellent thanks

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