Insulin rastvorym y chelovecheskyy genetically engineered | Rinsulin Rr for injection 100 IU /ml bottle 10 ml pack.

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Latin name

Rinsulin R

Release form



Bottle of 10 ml.

Pharmacological action

Short-acting human insulin obtained using recombinant DNA technology. It interacts with a specific receptor on the outer cytoplasmic membrane of cells and forms an insulin-receptor complex that stimulates intracellular processes, including synthesis of a number of key enzymes (hexokinase, pyruvate kinase, glycogen synthetase). The decrease in glucose in the blood is due to an increase in its intracellular transport, increased absorption and absorption by tissues, stimulation of lipogenesis, glycogenogenesis, and a decrease in the rate of glucose production by the liver.

The duration of action of insulin preparations is mainly due to the rate of absorption, which depends on several factors (for example, on the dose, method and place of administration), in this connection, the action profile of insulin is subject to significant fluctuations, both in different people and in the same person.

On average, after sc administration, the drug begins to act after 30 minutes, the maximum effect develops between 1 hour and 3 hours, duration of action is 8 hours.



The completeness of absorption and the onset of the effect of insulin depends on the route of administration (s / to, in / m), the injection site (abdomen, thigh, buttocks), dose (volume of injected insulin), the concentration of insulin in the drug.


Distributed throughout the tissues does not penetrate evenly across the placental barrier and into breast milk.

Metabolism and excretion

It is destroyed by insulinase mainly in the liver and kidneys. T1 / 2 is a few minutes. It is excreted by the kidneys (30-80%).


type 1 diabetes mellitus

type 2 diabetes mellitus: stage of resistance to oral hypoglycemic agents, partial resistance to these drugs (during combination therapy), intercurrent diseases

type 2 diabetes mellitus in pregnant

emergency conditions in patients with diabetes mellitus, accompanied by decompensation of carbohydrate metabolism.


increased individual sensitivity to insulin or any of the components of rinsulin P


Use during pregnancy and lactation

There are no restrictions on the treatment of diabetes mellitus with insulin during pregnancy, because insulin does not cross the placental barrier. When planning pregnancy and during it, it is necessary to intensify the treatment of diabetes. The need for insulin usually decreases in the first trimester of pregnancy and gradually increases in the second and third trimesters.

During childbirth and immediately after birth, insulin demand may decrease dramatically. Shortly after birth, the need for insulin quickly returns to the level that was before pregnancy.

There are no restrictions on the treatment of diabetes mellitus with insulin during breastfeeding. However, it may be necessary to reduce the dose of insulin, therefore, careful monitoring for several months is necessary before stabilizing the need for insulin.


1 ml of suspension contains human insulin human genetic engineering 100 IU

Dosage and administration

The drug is intended for SC, in / m and / in the introduction. The dose and route of administration of the drug are determined by the doctor individually in each case, based on the concentration of glucose in the blood.

On average, the daily dose of the drug ranges from 0. 5 to 1 IU / kg body weight (depending on the individual characteristics of the patient and the concentration of blood glucose).

The temperature of the injected insulin should correspond to room temperature.

The drug is administered 30 minutes before a meal or a snack containing carbohydrates.

With monotherapy with the drug, the frequency of administration is 3 times / day (if necessary, 5-6 times / day). At a daily dose exceeding 0.6 IU / kg, it is necessary to enter in the form of 2 or more injections in various areas of the body.

The drug is usually administered sc to the anterior abdominal wall. Injections can also be done in the thigh, buttock or deltoid region of the shoulder. It is necessary to change the injection site within the anatomical region to prevent the development of lipodystrophy.

Caution is required when administering insulin so as not to enter the blood vessel during injection. After the injection, the injection site should not be massaged. Patients should be trained in the proper use of the insulin delivery device.

In / m and in / in the drug can be administered only under medical supervision.

Rinsulin® P is short-acting insulin and is usually used in combination with medium-acting insulin (Rinsulin® NPH).

Rules for the administration of the drug

Do not use the drug if a solution appears in the solution.

When using only one type of insulin

1. Disinfect the rubber membrane of the vial.

2. Pour air into the syringe in the volume corresponding to the required dose of insulin. Introduce air into the vial of insulin.

3. Turn the vial with the syringe upside down and draw the desired dose of insulin into the syringe. Remove the needle from the vial and remove air from the syringe. Check the accuracy of the dose of insulin.

4. Inject immediately.

If you need to mix two types of insulin

1. Disinfect the rubber membranes of the vials.

2. Immediately before dialing, a vial of long-acting (cloudy) insulin should be rolled between the palms of the hands until the insulin becomes uniformly white and cloudy.

3. Pour air into the syringe in an amount corresponding to the dose of cloudy insulin. Introduce air into the vial with cloudy insulin and remove the needle from the vial.

4. Pour air into the syringe in the volume corresponding to the dose of short-acting insulin (clear). Introduce air into a transparent insulin vial. Turn the vial with the syringe upside down and collect the required dose of clear insulin. Remove the needle and remove air from the syringe. Check the correctness of the dose.

5. Insert the needle into the vial with cloudy insulin, turn the vial with the syringe upside down, and collect the required dose of insulin. Remove air from the syringe and check if the dose is correct. Inject an injected insulin mixture immediately.

6. You should always type insulins in the same sequence as described above.

Injection Procedure It is necessary to sanitize the area of ​​the skin where insulin will be injected.

With two fingers, collect a fold of skin, insert the needle into the base of the fold at an angle of about 45 ° and inject insulin under the skin.

After the injection, the needle should be left under the skin for at least 6 seconds to ensure that the insulin is fully inserted.

If blood appears at the injection site after removing the needle, lightly squeeze the injection site with a swab moistened with a disinfectant solution (such as alcohol).

It is necessary to change the injection site.

Side effects

Side effect due to the effect on carbohydrate metabolism: hypoglycemic conditions (pallor of the skin, increased sweating, palpitations, tremors, chills, hunger, agitation, paresthesia of the oral mucosa, headache, dizziness, decreased visual acuity). Severe hypoglycemia can lead to the development of hypoglycemic coma.

Allergic reactions: skin rash, Quincke’s edema, anaphylactic shock.

Local reactions: hyperemia, swelling and itching at the injection site, with prolonged use – lipodystrophy at the injection site.

Other: edema, transient decrease in visual acuity (usually at the beginning of therapy).

The patient should be informed that if he noted the development of hypoglycemia or had an episode of loss of consciousness, he should immediately inform the doctor.

If any other side effects are not described above, the patient should also consult a doctor.

Drug Interaction

There are a number of medicines that affect your insulin requirement.

Hypoglycemic action of insulin is enhanced by oral hypoglycemic drugs, MAO inhibitors, ACE inhibitors, carbonic anhydrase inhibitors, non-selective beta-blockers, bromocriptine, octreotide, sulfanylamides, anabolic steroids, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylphilin, preparophylline,

Hypohlykemycheskoe action Insulin oslablyayut glucagon somatropyn, estrogens, oral contraceptives, corticosteroids, yodsoderzhaschye tyreoydn e hormon , thiazide diuretics, loop diuretics, heparin, tricyclic antydepressant , sympathomimetic, danazol, clonidine, эpynefryn, blockers of histamine H1 receptors blockers medlenn h kaltsyev h channels, diazoxide, morphine, phenytoin, nicotine.

Under the influence of reserpine and salicylates, both attenuation and intensification of the drug are possible.

Pharmaceutically incompatible with solutions of other medicines.


Hypoglycemia may develop with an overdose.

Treatment: mild hypoglycemia can be eliminated by the patient himself, taking in sugar or carbohydrate-rich foods. Therefore, patients with diabetes mellitus are advised to carry with them sugar, sweets, cookies or sweet fruit juice.

In severe cases, when the patient loses consciousness, 40% dextrose (glucose) solution is introduced into the patient, in / m, n / a, in / in – glucagon. After regaining consciousness, the patient is advised to eat carbohydrate-rich foods to prevent hypoglycemia from developing again.

Storage conditions

The drug should be stored out of the reach of children, protected from light,

place at a temperature of 2 ° to 8 ° C

do not freeze


2 years.

Deystvuyuschee substances

Insulin rastvorym y chelovecheskyy genetically Inzhenernyi

dosage form

dosage form


Additional information


3 reviews for Insulin rastvorym y chelovecheskyy genetically engineered | Rinsulin Rr for injection 100 IU /ml bottle 10 ml pack.

  1. Robert

    Very good for my knee pain

  2. Kyle

    Good buy.

  3. Christine

    item was delivered ahead of of schedule, good seller

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