Solution for intracavitary and external use 1% light yellow with a greenish tint, transparent.
10 amp. 10 ml each.
Dioxidine is a broad-spectrum antibacterial bactericidal drug.
Active against: Proteus vulgaris, Pseudomonas aeruginosa, Friedlander bacillus, Escherichia coli, Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp, Staphylococcus spp, Streptococcus spprobenifenta curfens.
Acts on strains of bacteria resistant to other antibacterial agents, including antibiotics. It has no local irritating effect. Perhaps the development of drug resistance of bacteria. The treatment of burns and purulent-necrotic wounds promotes faster cleaning of the wound surface, stimulates reparative regeneration and marginal epithelization, and favorably affects the course of the wound process.
Septic conditions (including in patients with a burn disease), purulent meningitis, purulent-inflammatory processes with symptoms of generalization. Intracavitary – purulent processes in the chest and abdominal cavity: purulent pleurisy, empyema, peritonitis, cystitis, empyema of the gallbladder, prevention of infectious complications after catheterization of the bladder.
– Adrenal insufficiency (including history).
Use with caution in renal failure.
Use during pregnancy and lactation
If necessary, the appointment of the drug during lactation should decide whether to stop breastfeeding. In experimental studies, it was shown that dioxidine has a teratogenic and embryotoxic effect, has mutagenic properties. Given this, women of childbearing age are prescribed the drug only if other antimicrobials are ineffective.
Dioxidine is prescribed only for adults. Before starting a course of treatment, a tolerance test of the drug is carried out, for which 10 ml of a 1% solution is injected into the cavity. In the absence of side effects within 3-6 hours (dizziness, chills, fever), course treatment is started.
Dioxidine is prescribed only for severe forms of infectious diseases or for the ineffectiveness of other antibacterial drugs, including cephalosporins II-IV generations, fluoroquinolones, carbapenems.
In chronic renal failure, the dose is reduced.
With the appearance of age spots, increase the duration of a single dose to 1.5-2 hours, reduce the dose, prescribe antihistamines or cancel Dioxidin.
In the case of precipitation of dioxidine crystals in ampoules with a solution during storage (at a temperature below 15 ° C) they are dissolved by heating the ampoules in a boiling water bath with shaking until the crystals are completely dissolved (clear solution). If, upon cooling to 36-38 ÐÂ° Ð Ð, the crystals do not fall out again, the preparation is suitable for use.
1 ml of the solution contains: hydroxymethylquinoxylindioxide (1,4-dioxide 2,3-bis- (hydroxymethyl) quinoxaline) 10 mg.
Dosage and Administration
Dioxidine is administered intravenously. In severe septic conditions, a 0.5% solution for injection is administered, previously diluted in 5% dextrose solution or in 0.9% NaCl solution to a concentration of 0.1-0.2%. The highest single dose is 300 mg, daily – 600 mg. Dioxidine is administered intracavitary. In the cavity, the solution is injected through a drainage tube, catheter or syringe, 10-50 ml of a 1% solution.
Allergic reactions. After iv and intracavitary administration of dioxidine – headache, chills, hyperthermia, nausea, vomiting, diarrhea, muscle twitching.
In the dark place at a temperature of no higher than 20 ° C.
Form of Treatment
simply entails dlya naruzhnogo primeneniya