cryptococcosis, including cryptococcal meningitis and other localizations of this infection (including in the lungs, on the skin), both in patients with a normal immune response, and with various forms of immunosuppression (including in patients with AIDS, with organ transplantation) can be used for the prevention of cryptococcal infection in AIDS patients with
generalized candidiasis, including candidaemia, disseminated candidiasis and other forms of invasive candida infections (infections of the peritoneum, endocardium, eyes, respiratory and urinary tract) candidiasis,. Treatment can be carried out in patients with malignant neoplasms, patients in intensive care units, patients undergoing a course of cytostatic or immunosuppressive therapy, as well as in the presence of other factors predisposing to the development of candidiasis
candidiasis of the mucous membranes, including the oral cavity and pharynx (including atrophic candidiasis of the oral cavity associated with wearing dentures), the esophagus, non-invasive bronchopulmonary candidiasis prevention of recurrence of oropharyngeal candidiasis in AIDS patients
genital candidiasis: vaginal candidiasis (acute and chronic relapse), prophylactic use to reduce the frequency vaginal candidiasis (3 or more episodes per year) candidal balanitis
prevention of fungal infections in patients with malignant neoplasms are located to such infections as a result of chemotherapy with cytostatics or radiation therapy of
mycosis of the skin, including mycoses of the feet, body, inguinal region, pityriasis, onychomycosis of candidiasis of the skin
deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with normal immunity.
hypersensitivity to the drug or structurally similar azole compounds
simultaneous administration of terfenadine or astemizole and other drugs that extend the QT
interval for children (up to 3 years).
Precautions: hepatic and / or renal failure, concomitant use of potentially hepatotoxic drugs, alcoholism.
1 capsule contains:
Active ingredient: fluconazole 150 mg
Excipients: lactose monohydrate starch pregelatinized silicon dioxide colloidal magnesium sodium stearate lauryl sulfate.
Side effects of the
From the digestive system: changes in taste, vomiting, nausea, diarrhea, flatulence, abdominal pain, rarely – impaired liver function (jaundice, hepatitis, hepatonecrosis, hyperbilirubinemia, increased activity of ALT, AST, ALP).
From the nervous system: headache, dizziness, rarely – cramps.
From the hemopoietic organs: rarely – leukopenia, thrombocytopenia, neutropenia, agranulocytosis.
Allergic reactions: skin rash, rarely – malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), anaphylactoid reactions.
Other: rarely – impaired renal function, alopecia, hypercholesterolemia, hypertriglyceridemia, hypokalemia.
When using fluconazole with warfarin, the increase in PV (on average by 12%). In this regard, it is recommended to carefully monitor the PV indicators in patients receiving the drug in combination with coumarin anticoagulants.
Fluconazole increases the plasma half-life of oral hypoglycemic sulfonylurea derivatives (chlorpropamide, glibenclamide, glipizide, tolbutamide) in healthy people. The combined use of fluconazole and oral hypoglycemic agents in patients with diabetes is allowed, but the doctor should keep in mind the possibility of developing hypoglycemia.
The simultaneous use of fluconazole and phenytoin can lead to an increase in the concentration of phenytoin in the plasma to a clinically significant degree. Therefore, if it is necessary to use these drugs together, it is necessary to monitor phenytoin concentrations with dose adjustment in order to maintain the drug level within the therapeutic interval.
Combination with rifampicin reduces AUC by 25% and shortens plasma T1 / 2 of fluconazole by 20%. Therefore, it is advisable to increase the dose of fluconazole to patients receiving rifampicin at the same time.
It is recommended to monitor the concentration of cyclosporine in the blood in patients receiving fluconazole, as the use of fluconazole and cyclosporine in patients with a transplanted kidney (when taking fluconazole at a dose of 200 mg / day) leads to a slow increase in the concentration of cyclosporine in plasma.
Patients who receive high doses of theophylline or who are likely to develop theophylline intoxication, should be monitored for the early detection of symptoms of theophylline overdose, as taking fluconazole leads to a decrease in the average clearance rate of theophylline from plasma.
With the simultaneous use of fluconazole and terfenadine, cisapride, cases of adverse reactions from the heart, including paroxysms of ventricular tachycardia (torsades de pointes), have been described.
The simultaneous use of fluconazole and hydrochlorothiazide can lead to an increase in the concentration of fluconazole in plasma by 40%.
There are reports of the interaction of fluconazole and rifabutin, accompanied by an increase in serum levels of the latter. With the simultaneous use of fluconazole and rifabutin, cases of uveitis have been described. It is necessary to carefully observe patients simultaneously receiving rifabutin and fluconazole.
In patients receiving a combination of fluconazole and zidovudine, an increase in the concentration of zidovudine is observed, which is caused by a decrease in the conversion of the latter to its main metabolite, therefore, an increase in side effects of zidovudine is expected.
Symptoms: hallucinations, paranoid behavior.
Treatment: symptomatic, gastric lavage, forced diuresis. Hemodialysis within 3 hours reduces the plasma concentration by approximately 50%.
In a dry, dark place at 10-25 ° C.
Conditions for the drugstore from
Without a prescription