Latin name srdlaz
Powder for the preparation of a solution for iv and v / m administration.
vial 1 g
Cefazolin is a semi-synthetic cephalosporin antibiotic of the first generation with a wide spectrum of action for parenteral use. It is bactericidal, inhibiting the biosynthesis of the bacterial cell wall. Active against gram-positive bacteria: Staphylococcus spp. (excluding methicillin-resistant strains), Streptococcus spp. (except Streptococcus faecalis) gram-negative bacteria: Escherichia coli, Proteus mirabilis, Klebsiella spp., Neisseria gonorrhoeae, Treponema spp., Enterobacter aerogenes, Haemophilus influenzae.
Not effective against Pseudomonas aeruginosa, indole-positive strains of Proteus spp., Mycobacterium tuberculosis, Serratia spp., anaerobic microorganisms, methicillin-resistant strains of Staphylococcus spp.
Bacterial infections of the upper and lower respiratory tract, urinary and biliary tract, pelvic organs, skin and soft tissues, bones and joints, endocarditis, sepsis, peritonitis, otitis media, osteomyelitis, mastitis, wound, burn and postoperative infections , gonorrhea and other diseases caused by microorganisms sensitive to cefazolin. Prevention of surgical infections in the pre- and postoperative period.
Hypersensitivity to cephalosporins and other beta-lactam antibiotics pregnancy age up to 1 month.
Precautions – renal / hepatic failure, pseudomembranous enterocolitis.
Patients who have had a history of allergic reactions to penicillins, carbapenems, may be hypersensitive to cephalosporin antibiotics. With the development of allergic reactions, the administration of the drug should be discontinued and appropriate desensitizing therapy should be prescribed.
With the development of renal failure, the dose of the drug should be reduced and treatment should be further carried out under the control of the dynamics of the urea nitrogen and creatinine levels in the blood.
During treatment with cefazolin, it is possible to obtain positive direct and indirect Coombs samples, as well as a false positive urine reaction to sugar.
When prescribing the drug, exacerbation of gastrointestinal diseases, especially colitis, is possible.
When thawing, the solution remains stable for 10 days when stored in the refrigerator (5 degrees C) or 48 hours at room temperature.
Safety of use in premature infants and children of the first year of life has not been established.
Active ingredient: cefazolin (in the form of sodium salt) 1.0 g
Dosage and administration of
cefazolin is administered in / m and / in (jet and drip).
When i / m is administered, a single dose for adults is 0.25-1 g every 8-12 hours. The average daily dose is 0.75-1.5 g.
For severe infections, 0.5-1 g is prescribed every 6-8 hours. The maximum daily dose is 6 g (in rare cases – 12 g).
For the prevention of postoperative complications, a dose of 1 g is administered 30 minutes before surgery, 0.5-1 g during surgery and 0 at a time. 5-1 g every 6-8 hours for a day after surgery.
For children older than 1 month. prescribed in a daily dose of 25-50 mg / kg, with severe infections – 100 mg / kg. The daily dose is divided into 2-3 doses.
When prescribing the drug, the sensitivity of the isolated pathogens to it should be determined using disks containing 30 Î¼g cefazolin.
In case of impaired renal excretory function in adults, the drug dose is reduced, the intervals between administrations are increased. The initial dose is 500 mg, regardless of the degree of impaired renal function.
Duration of treatment is 7-14 days or more, depending on the severity of the disease.
Allergic reactions: hyperthermia, skin rash, urticaria, pruritus, bronchospasm, eosinophilia, Quincke’s edema, arthralgia, anaphylactic shock, erythema multiforme, malignant exudative erythema (erythema).
From the nervous system: cramps.
From the urinary system: in patients with renal failure when using the drug in large doses (6 g), kidney failure may develop.
From the digestive system: nausea, vomiting, diarrhea, abdominal pain, pseudomembranous enterocolitis, rarely – cholestatic jaundice, hepatitis.
From the hemopoietic organs: leukopenia, neutropenia, thrombocytopenia, thrombocytosis, hemolytic anemia.
Local reactions: with i / m administration – pain (at the injection site), with i / v administration – phlebitis.
Other: gastrointestinal upsets, dysbiosis, superinfection caused by antibiotic-resistant strains.
Synergism of antibacterial action is noted with simultaneous use of the drug with aminoglycosides, vancomycin, rifampicin.
Concomitant use with anticoagulants and diuretics (furosemide, ethacrylic acid) is not recommended.
With the simultaneous use of cefazolin, a blockage of its tubular secretion occurs. Aminoglycosides increase the risk of kidney damage.
Pharmaceutically incompatible with aminoglycosides (mutual inactivation). Drugs that block tubular secretion increase blood concentration, slow down excretion, and increase the risk of toxic reactions.
In a dry, dark place at 25 ° C.
Form of Treatment
simply entails dlya inaektsiy and infusing
Children over 1 month old, Adult doctor
Burns, From skin infections, From osteomyelitis, Bronchitis, From otitis media, From urinary tract infections, Purulent wounds, From pneumonia
Possible Product Names
Cefazolin Pore. d / pr-r solution for in / ven.and in / mouse.input. bottle 1 g