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butamirate |

(5 customer reviews)

$27.00 $19.00

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Description

Release form

Drops

Packing

Drops in a bottle of 20 ml.

Pharmacological action

Codelac Neo – antitussive, expectorant, bronchodilating, anti-inflammatory.

Pharmacodynamics

Antitussive non-opioid drug, has a direct effect on the cough center. Butamyrate citrate is neither chemically nor pharmacologically related to opium alkaloids. It has an antitussive, expectorant, moderate bronchodilating and anti-inflammatory effect, improves spirometry (reduces airway resistance) and blood oxygenation.

Pharmacokinetics

Drops for oral administration

Absorption. After oral administration, the drug is rapidly and completely absorbed from the digestive tract. After taking 150 mg of Cmax butamirate, the main metabolite (2-phenylbutyric acid) in the blood plasma is reached after about 1.5 hours and is 6.4 μg / ml.

Distribution and metabolism. The hydrolysis of butamirate, initially to 2-phenylbutyric acid and diethylaminoethoxyethanol, begins in the blood. These metabolites also have antitussive activity, and, like butamirate, to a large extent (about 95%) bind to plasma proteins, which causes their long-term T1 / 2. 2-phenylbutyric acid is partially metabolized by hydroxylation.

With repeated use of the drug, cumulation is not observed.

Withdrawal. T1 / 2 is 6 hours. All three metabolites are excreted mainly in the urine. Moreover, 2-phenylbutyric acid is mainly excreted in the form bound to glucuronic acid.

Indications

Dry cough of any etiology (for colds, flu, whooping cough and other conditions)

suppression of cough in the preoperative and postoperative period, during surgical interventions and bronchoscopy.

Contraindications

hypersensitivity to the drug

pregnancy (I trimester)

breastfeeding period

fructose intolerance (drops for oral administration, syrup)

lactose intolerance, lactase deficiency, glucose-galactose malabsorption (film-coated modified release tablets)

children under 2 months of age (drops for oral administration), up to 3 years (syrup), up to 18 years old (film-coated tablets with modified release).

Use during pregnancy and lactation

There is no data on the safety of the drug during pregnancy and its passage through the placental barrier.

The use of the drug in the first trimester of pregnancy is contraindicated.

In the second and third trimesters of pregnancy, the use of the drug is possible taking into account the ratio of benefits for the mother and potential risk to the fetus.

The penetration of the drug into breast milk has not been studied, therefore, the use of the drug during breastfeeding is not recommended.

Special instructions

There is a danger when using the drug in patients with a tendency to develop drug dependence, with liver diseases, alcoholism, epilepsy, and brain diseases.

Drops for oral administration, syrup. The drug can be used by patients with diabetes mellitus, because sucrose or glucose is not used as a sweetener.

film-coated tablets with a modified release. Each tablet contains 241 mg of lactose. The drug is contraindicated in patients with lactose intolerance, lactase deficiency, glucose-galactose malabsorption.

Influence on the ability to drive vehicles and work with mechanisms. It is recommended to refrain from driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions, as the drug may cause drowsiness or dizziness.

Composition

5 ml syrup contains:

Active ingredient:

butyrate citrate (in terms of 100% substance) 100 mg

Excipients:

sorbitol (Neosorb 70/70 V, sorbitol syrup) – 8100 mg

glycerol (glycerin) – 5800 mg

ethanol (ethyl alcohol 95%) – 61 mg

sodium saccharin – 23 mg

benzoic acid – 23 mg

vanillin – 23 mg

sodium hydroxide solution 30% – 1 0 mg

purified water – up to 20 ml

Dosage and administration

For children from 2 to 12 months – 10 drops 4 times a day from 1 year to 3 years – 15 drops 4 times a day over 3 years – 25 drops 4 times a day.

Before using the drug in children under 2 years of age, consult a doctor.

Drops for oral administration, 5 mg / ml (1 ml contains 22 drops).

Side effects

From the side of the central nervous system: dizziness that occurs when you stop taking the drug or reduce the dose of drowsiness.

From the digestive system: nausea, vomiting, diarrhea.

From the skin: exanthema.

Allergic reactions: skin rash, itching.

Drug Interactions

No drug interactions for butamirate have been described.

During the treatment with the drug, it is not recommended to drink alcoholic beverages, as well as drugs that depress the central nervous system (including sleeping pills, antipsychotics, tranquilizers).

Overdose

Symptoms: nausea, vomiting, drowsiness, diarrhea, abdominal pain, dizziness, irritability, decreased BP, impaired movement coordination.

Treatment: appointment of activated charcoal, gastric lavage, salt laxatives, symptomatic therapy (as indicated).

Storage conditions

At a temperature not exceeding 25 ° C.

Shelf life

2 years

Deystvuyushtee substance

Butamirate

Conditions of drugstore

p90 without prescription recipe

Pharmstandard-Leksredstva, Russia

Additional information

Brand

5 reviews for butamirate |

  1. Mary

    Great Thanks

  2. Christy

    THANKS!! good product, fast service

  3. Roderick

    Great seller highly recommend!!

  4. Sarah

    Thank you😀

  5. Jeff

    awesome!

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