Pharmacological action of
Aversect K & C has a wide spectrum of antiparasitic action, is active against roundworms Toxocara canis, Toxocara mystax, Toxascaris leonina, Uncinaria spp., Ancylostoma spp., Dirofilaria imulisarispis trichtis, Trichiopis trisoptis Trichtis, trichioptis Trichisoptis, Trichioptera sul. Demodex canis, Notoedres spp. and insects Ctenocephalides spp., Linognathus spp., Trichodectes canis, parasitizing on dogs and cats. The mechanism of action of aversectin C1 lies in its effect on the value of the current of chlorine ions through the membranes of the nerve and muscle cells of the parasite. The main targets are glutamate-sensitive chlorine channels, as well as gamma-aminobutyric acid receptors. A change in the current of chlorine ions disrupts the conduction of nerve impulses, which leads to paralysis and death of the parasite. After parenteral administration, aversectin C1 is rapidly absorbed from the injection site and is distributed in the organs and tissues of the animal, providing a long-lasting parasitocidal effect. The maximum level of aversectin C1 in the blood is observed 24 hours after subcutaneous administration of the drug, followed by a decrease by 5 days. The drug is excreted from the body of the animal with urine and bile, in lactating females – partially with milk. The K&C reverse according to the degree of influence on the organism of warm-blooded animals belongs to low-hazard substances and in the recommended doses does not have an embryotoxic, teratogenic and mutagenic effect.
Assign to dogs and cats for prophylactic and therapeutic purposes in case of nematodoses and arachno-entomoses (demodicosis, otodectosis, notothedrosis, sarcoptosis, sifunculosis).
Increased individual sensitivity to the drug. Use with caution puppies and kittens up to 7 weeks of age, pregnant and lactating females, as well as weakened and old animals. Due to the pronounced breed sensitivity to avermectins, the drug should not be prescribed to dogs of the breed Collie, Bobtail and Sheltie. Do not use in conjunction with avermectin-containing and other antiparasitic drugs for treating animals.
Aversect K&C contains an avermectin complex (aversectin C1) derived from the vital products of the soil fungus Streptomyces avermitilis, as well as auxiliary components.
Dosage and administration
Aversect K&C is administered to animals in compliance with aseptic and antiseptic rules subcutaneously or intramuscularly at the rate of 0.2 mg of active substance (aversectin C1) per 1 kg of animal weight, which corresponds to 0.4 for medium and large dogs ml of 0.5% Aversect K & C solution per 10 kg of animal weight, dogs weighing less than 10 kg and cats – 0.1 ml of 0.2% Aversect K & C solution per 1 kg of animal weight. With nematodoses and entomoses, the drug is used once, with sarcoptosis, notoedrosis and otodectosis twice with an interval of 7-10 days, with demodecosis repeatedly before the recovery of the animal with an interval of 7-10 days. The clinical recovery of the animal is confirmed by two negative results of acarological studies of skin scrapings. Treatment of animals with acarosis is recommended to be carried out comprehensively with the use of immunomodulating, antifungal and antimicrobial drugs. In order to prevent re-infection with fleas, the animal is replaced with litter or treated with an insecticidal agent in accordance with the instructions for use.
Side effects of
Allergic reactions are possible in hypersensitive animals. With proper use and dosage, side effects are usually not observed. With a significant overdose of the drug in animals, the appearance of edema at the injection site, impaired coordination of movements, lying position is possible. In this case, it is necessary to stop the administration of the drug.
In a dry place, protected from direct sunlight and out of the reach of children and animals. Separated from food and feed at temperatures from 0 to 30? C.
2 years, after opening the bottle – no more than 24 days.
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