5% cream for external use in aluminum tubes of 3, 5, 10 g. Together with the instructions for use, they are placed in a pack of cardboard.
Pharmacological action of
Acyclovir is active against Herpes simplex types 1 and 2, Varicella zoster virus, Epstein Barr virus and cytomegaloviruses. The thymidine kinase of virus-infected cells activates acyclovir into acyclovir mono-, di- and triphosphate through a series of sequential reactions. The latter interacts with viral DNA polymerase and integrates into DNA, which is synthesized for new viruses. Thus, defective viral DNA is formed, which leads to suppression of replication of new generations of viruses.
Pharmacokinetics: When used locally, it is practically not absorbed through damaged skin, and does not enter the systemic circulation.
Infections of the skin and mucous membranes caused by Herpes simplex virus types 1 and 2, genital herpes, herpes zoster, chickenpox.
Hypersensitivity to acyclovir and other components of the drug.
Precautions – pregnancy, lactation, dehydration, renal failure.
Pregnancy and lactation
There have been no adequate and well-controlled clinical trials of the safety of the drug during pregnancy. Use is indicated only in cases where the intended benefit to the mother outweighs the potential risk to the fetus.
During the treatment period, it is necessary to resolve the issue of terminating breastfeeding.
To achieve the maximum therapeutic effect, it is necessary to start using the drug as soon as possible after the onset of infection (at the first signs of the disease: burning, itching, tingling, sensation of tension and redness).
Cream is not recommended to be applied to the mucous membranes of the mouth and eyes, as the development of severe local inflammation is possible. When treating genital herpes, you should avoid sexual contact or use condoms, since the use of acyclovir does not prevent the transmission of the virus to partners.
Active ingredient – acyclovir 5 g
Excipients – nipazole. nipagin, cremophor A6. Cremophor A25. cetyl alcohol, propylene glycol, liquid paraffin, purified water.
Dosage and Administration
Externally. The drug is applied 5 times a day (every 4 hours) with a thin layer on the affected and adjacent skin areas. The cream is applied either with a cotton swab or with clean hands to avoid additional infection of the affected areas. Therapy should be continued until the crust forms on the vesicles, or until they completely heal. The duration of therapy is an average of 5 days and should not exceed 10 days.
Hyperemia, dryness, peeling of the skin, burning sensation, inflammation in contact with mucous membranes. Perhaps the development of allergic dermatitis.
With topical application, no interaction with other drugs was detected.
List B. At 12 to 15 ° C. Store inout of reach of children.
Terms leave through pharmacies
For tall, children prescribed by a doctor, the doctor Pregnant intended